Amyloid β Protein-(1–42) Forms Calcium-permeable, Zn2+-sensitive Channel
نویسندگان
چکیده
منابع مشابه
Membrane Incorporation, Channel Formation, and Disruption of Calcium Homeostasis by Alzheimer's β-Amyloid Protein
Oligomerization, conformational changes, and the consequent neurodegeneration of Alzheimer's β-amyloid protein (AβP) play crucial roles in the pathogenesis of Alzheimer's disease (AD). Mounting evidence suggests that oligomeric AβPs cause the disruption of calcium homeostasis, eventually leading to neuronal death. We have demonstrated that oligomeric AβPs directly incorporate into neuronal memb...
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Alzheimer’s disease (AD) is a severe senile type of dementia that affects a large number of elderly people. It is estimated that 5.4 million people in the worldwide are affected by this disease in 2011 and this number continues to grow yearly. AD is characterized by profound memory loss and severe cognitive decline. The pathological hallmarks of AD are the presence of numerous extracellular dep...
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OBJECTIVE Calcium-permeable cation channel TRPV2 is expressed in pancreatic beta-cells. We investigated regulation and function of TRPV2 in beta-cells. RESEARCH DESIGN AND METHODS Translocation of TRPV2 was assessed in MIN6 cells and cultured mouse beta-cells by transfecting TRPV2 fused to green fluorescent protein or TRPV2 containing c-Myc tag in the extracellular domain. Calcium entry was a...
متن کاملThe versatile nature of the calcium-permeable cation channel TRPP2.
TRPP2 is a member of the transient receptor potential (TRP) superfamily of cation channels, which is mutated in autosomal dominant polycystic kidney disease (ADPKD). TRPP2 is thought to function with polycystin 1-a large integral protein-as part of a multiprotein complex involved in transducing Ca(2+)-dependent information. TRPP2 has been implicated in various biological functions including cel...
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We investigated the mechanism whereby ions cross dihydropyridinesensitive (L-type) Ca channels in guinea pig ventricular myocytes. At the singlechannel level, we found no evidence o f an anomalous mole-fraction effect like that reported previously for whole-cell currents in mixtures o f Ba and Ca. With the total concentration o f Ba + Ca kept constant at 10 (or 110) mM, neither conductance nor ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1998
ISSN: 0021-9258
DOI: 10.1074/jbc.273.22.13379